After Mike Delfino's death, Susan Mayer makes the significant decision to leave Wisteria Lane.
Mike's death was a profound personal loss for Susan, serving as the show's main "disaster" for her rather than a traditional broader calamity. He was tragically shot to death by a vengeful loan shark directly on her doorstep. This devastating event directly led to Susan's choice to move away from Wisteria Lane, marking a pivotal turning point in her life and her departure from the iconic neighborhood.
