The composition of Miochol, specifically the Miochol-E formulation, includes an active pharmaceutical ingredient and several excipients crucial for its function and stability.
Understanding Miochol-E's Composition
Miochol-E is an ophthalmic solution primarily used to achieve rapid and complete miosis (pupil constriction) during surgical procedures. Its precise formulation is designed to ensure therapeutic effectiveness and patient safety.
Active Ingredient
The primary component responsible for Miochol-E's therapeutic action is:
- Acetylcholine Chloride: Each dose contains 20 mg of this active ingredient. Acetylcholine chloride functions as a neurotransmitter, playing a key role in the eye's muscle contractions that lead to pupil constriction.
Inactive Ingredients (Excipients)
To maintain the solution's stability, sterility, and physiological compatibility, Miochol-E incorporates a specific blend of inactive ingredients, also known as excipients:
| Ingredient | Primary Role/Type |
|---|---|
| Mannitol | Bulking agent, often used for tonicity adjustment |
| Sodium Acetate | Buffer, helps maintain the solution's pH level |
| Magnesium Chloride | Electrolyte, contributes to tonicity and solution balance |
| Potassium Chloride | Electrolyte, contributes to tonicity and solution balance |
| Calcium Chloride | Electrolyte, contributes to tonicity and solution balance |
| Water for Injections | Solvent, provides the liquid base for the solution |
These excipients are carefully selected to create an isotonic solution, which means it has a similar salt concentration to body fluids, making it well-tolerated when administered to the eye. This comprehensive composition ensures the effective and safe delivery of acetylcholine chloride for its intended ophthalmic use.
