To thoroughly evaluate potential leachables from materials, a diverse range of solvents, categorized by their polarity, are typically employed.
Leachable studies are crucial for assessing the risk of harmful substances migrating from a material into a product. To ensure a comprehensive extraction of various compounds, solvents with differing polarities are used. This approach helps simulate diverse real-world conditions and ensures that both polar and nonpolar extractable substances are identified.
The solvents commonly utilized in leachable studies can be broadly classified into three main types based on their polarity:
Types of Solvents Used in Leachable Studies
| Polarity | Examples of Solvents |
|---|---|
| Polar | Water |
| Semipolar | Dimethyl sulfoxide, Acetonitrile, Methanol, Acetone, Ethanol, Tetrahydrofuran, n-Propyl alcohol, iso-Propyl alcohol, Dichloromethane |
| Nonpolar | Toluene, Cyclohexane, Heptane, n-Hexane |
By using a spectrum of solvents from polar to nonpolar, scientists can effectively extract a wide array of chemical compounds that might leach from a material. This systematic approach ensures robust data collection for risk assessment.
