Myeloma neuropathy primarily manifests as weakness, numbness, and a "pins and needles" sensation, resulting from nerve damage caused by abnormal proteins produced by myeloma cells.
Understanding Myeloma Neuropathy
Myeloma, a cancer of plasma cells, can sometimes lead to complications that affect the nervous system. One such complication is peripheral neuropathy, a condition where peripheral nerves, which are outside of the brain and spinal cord, become damaged. In the context of myeloma, this nerve damage occurs when the abnormal proteins produced by the cancerous cells interfere with nerve function.
Key Symptoms of Myeloma Neuropathy
The symptoms of myeloma neuropathy are directly related to the affected nerves and can vary in severity. Common signs include:
- Weakness: This can affect various parts of the body, potentially making everyday tasks difficult. It might manifest as a loss of strength in the limbs, making it hard to lift objects or walk steadily.
- Numbness: Patients may experience a reduced sensation or complete loss of feeling in certain areas, often in the hands or feet. This can feel like a deadened or sleepy limb, affecting touch, temperature, or pain perception.
- "Pins and Needles" Sensation: This is a common and often uncomfortable tingling, prickling, or burning sensation, similar to when a limb "falls asleep" but can be persistent. It is medically known as paresthesia.
These symptoms arise because the abnormal proteins associated with myeloma can directly damage the delicate structure of the nerves. This interference disrupts the nerves' ability to transmit signals properly, leading to the characteristic sensory and motor disturbances.
