Unlike many other extended-release (ER) pain medications, crushing or cutting Xtampza ER (oxycodone) does not alter how the medication works. The drug is designed to maintain its intended release profile even if the capsule contents are compromised.
Understanding Xtampza ER's Unique Design
Most extended-release opioid medications are formulated to release their active ingredient slowly over many hours. If these types of medications are crushed, chewed, or cut, this controlled release mechanism can be bypassed. This leads to a rapid "dose dumping," where the entire dose is released at once, potentially causing a dangerous spike in medication levels in the bloodstream. This rapid absorption can increase the risk of serious side effects, including overdose and respiratory depression.
However, Xtampza ER is specifically engineered with a unique technology that prevents this dose dumping. Even if the contents of the capsule are crushed or cut, the medication continues to work in the same way it would if swallowed whole. This means it still releases the oxycodone gradually over time, as intended.
Key Differences When Xtampza ER is Crushed
Here's a comparison highlighting how Xtampza ER differs from many other extended-release opioids when its integrity is compromised:
| Feature | Most Extended-Release Opioids (when crushed) | Xtampza ER (when crushed) |
|---|---|---|
| Release Profile | Rapid, uncontrolled release (dose dumping) | Maintains extended, controlled release |
| Blood Levels | Can lead to a dangerous and sudden spike | Consistent and controlled levels maintained |
| Safety Implications | Increased risk of overdose, respiratory depression | Reduced risk of dose dumping-related adverse events |
| Medication Effectiveness | Altered, potentially leading to reduced effectiveness or toxicity | Works in the same way, as intended |
This unique formulation is a key distinction for Xtampza ER, providing a different safety profile if the medication is not taken intact. It allows the medication to continue providing extended pain relief without the significant risks associated with the physical manipulation of many other extended-release formulations.
