HATU stands for Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium. It is a crucial reagent widely utilized in organic chemistry, particularly in the field of peptide synthesis.
Understanding HATU: Its Full Name and Function
HATU, or Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium, is primarily known for its role as a peptide coupling reagent. This chemical compound plays a vital part in facilitating the formation of peptide bonds, which are the fundamental linkages that connect amino acids to create peptides and proteins.
How HATU Facilitates Peptide Synthesis
Peptide synthesis involves joining individual amino acids together in a specific sequence. HATU acts as an activating agent that helps to activate the carboxyl group of one amino acid, making it more susceptible to nucleophilic attack by the amino group of another amino acid. This activation promotes the efficient and rapid formation of a stable amide (peptide) bond.
- Key Role: HATU is a key chemical used to form a coupling reaction, creating a formation as part of peptide synthesis.
- Mechanism: It works by forming an active ester intermediate, which then readily reacts with an incoming amine.
- Efficiency: HATU is known for its high efficiency and minimal side reactions, making it a preferred choice for synthesizing complex peptides.
For those interested in the intricate processes of biomolecule creation, understanding reagents like HATU provides insight into the sophisticated techniques used in modern chemical synthesis. You can learn more about peptide coupling reagents on various chemical supplier and academic chemistry websites.
Commercial Availability of HATU
As a commonly used reagent in research and industrial settings, HATU is readily available from chemical suppliers. It can often be purchased in various quantities to suit different scales of synthesis:
| Catalog Size | Usage |
|---|---|
| 25g | Laboratory scale, small-batch synthesis |
| 100g | Medium-scale synthesis, regular lab use |
| 250g | Larger scale research, pilot projects |
| Bulk Quantity | Industrial applications, large-volume production |
Its availability in different sizes makes it accessible for various research and manufacturing needs in areas like pharmaceuticals, biotechnology, and materials science.
