Plegridy (peginterferon beta-1a) is typically dosed once every 14 days after an initial titration period.
Plegridy is administered as a subcutaneous (SC) or intramuscular (IM) injection. The dosing schedule is designed to gradually increase the dose to help patients adjust to the medication before reaching the full recommended dose.
Plegridy Dosing Schedule
The dosing involves an initial titration phase before the full maintenance dose is achieved:
| Dose Number | Amount (mcg) | Administration Day | Notes |
|---|---|---|---|
| Dose 1 | 63 | Day 1 | First injection, initial titration |
| Dose 2 | 94 | Day 15 | Second injection, further titration |
| Full Dose | 125 | Day 29 and onward | Recommended maintenance dose, every 14 days |
After the initial two titration doses, the full recommended dose of 125 mcg is given one time every 14 days. This consistent bi-weekly schedule ensures the medication's therapeutic effects are maintained.
Administration Details
- Route: Plegridy can be given by subcutaneous (SC) or intramuscular (IM) injection.
- Frequency: The standard maintenance frequency is once every 14 days (bi-weekly).
- Purpose of Titration: The initial lower doses (63 mcg and 94 mcg) help patients acclimate to the medication, potentially reducing initial side effects before reaching the full therapeutic dose.
Understanding the precise dosing schedule, including the initial titration and the long-term maintenance phase, is crucial for effective treatment with Plegridy.
