The molecular weight of ataxin proteins can vary significantly, primarily depending on the specific isoform. Specifically, for Ataxin 2 (ATXN2), its molecular weight ranges from 12 to 140 kilodaltons (kDa).
Understanding Ataxin Molecular Weight Variation
Ataxin proteins, particularly Ataxin 2, exhibit a wide range of molecular weights due to the presence of different protein isoforms. Isoforms are distinct versions of a protein that originate from the same gene. These variations can arise from processes such as alternative splicing of messenger RNA (mRNA), which leads to different combinations of exons, or from post-translational modifications. Consequently, these different forms can have varying lengths and compositions, directly influencing their molecular weight.
The significant range from 12 to 140 kDa for Ataxin 2 highlights this variability, indicating that different functional or truncated forms of the protein may exist within cells. This flexibility in protein size can be crucial for the diverse roles ataxin proteins play in cellular processes, which are often implicated in neurodegenerative diseases.
Key Details on Ataxin 2 Molecular Weight
To provide a clear overview, here's a summary of the observed molecular weight range for Ataxin 2:
| Protein | Molecular Weight Range (kDa) | Primary Reason for Variation |
|---|---|---|
| Ataxin 2 | 12 - 140 | Protein Isoforms |
For further information on the Ataxin 2 protein and its characteristics, you can refer to reputable scientific databases.
